Pepsinogen I (PGI, PGA)
| Product Name | Pepsinogen I |
| Source | Human Gastric Mucosa |
| Catalogue Number | 440-50 |
| Purity | > 90% (SDS-PAGE) |
| Purity Note | Typically > 96% (SDS-PAGE) |
| Form | Lyophilized |
| Protein | Reported mg protein/vial (A280nm, E0.1%=1.48) |
| Specific Activity | > 500 U/mg protein (After activation) |
| Unit Definition | One unit will produce a change in A280 of 0.001 per minute at pH 2.0 and 37°C, measured as TCA-soluble products from hemoglobin. |
| Appearance | White to off-white powder |
| Solubility | Clear, colorless liquid (1 mg/mL saline) |
| Reconstitution | After reconstitution maintain at or above pH 8.0 to avoid activation. |
| Formulation | Lyophilized from tris-chloride, pH 8.5. |
| Related Products | 440-52 - Pepsinogen II from human gastric mucosa 441-10 - Pepsin 1:10,000 from porcine gastric mucosa 435-10 - Mucin from porcine gastric mucosa |
| Recertification | 3 years |
| Storage | -20°C |
| Infectious Disease Testing | Negative or non-reactive at the donor level for anti HIV 1 and 2, anti HCV, syphilis (RPR) and HBsAg by FDA approved methods |
| Molecular Weight | 40,300 |
| Synonyms | Pepsinogen A, PG I, PGA, Pepsinogen 1 |
| E.C. Number | 3.4.23.1 |
| Gene | PGA3, PGA4, PGA5 |
Lee Biosolutions is the leading producer and supplier of human gastric Pepsinogen I (A) antigen as a cancer marker for medical research, clinical and biomedical manufacturing.
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of proteins after activation of acidic pH. It is synthesized as isoymogens and are classified into two groups, Pepsinogen I and Pepsinogen II).
Human PGA and PGC antigen have been investigated as a possible biomarker for early detection of, Gastric cancer (GC), adenoma (GA) and severe atrophic (diffuse or patchy) corpus gastritis.
It has been reported that human Pepsinogen I (PGA) levels were lower in atrophic corpus gastritis than in atrophic antral gastritis, and human pepsinogen I(PGA) levels were lower in advanced gastric cancer than early stage gastric cancer.
Lee Biosolutions, Inc
