Pepsinogen I (PGI, PGA)

Product Name	Pepsinogen I
Source	Human Gastric Mucosa
Catalogue Number	440-50
Purity	> 90% (SDS-PAGE)
Purity Note	Typically > 96% (SDS-PAGE)
Form	Lyophilized
Protein	Reported mg protein/vial (A_280nm, E^0.1%=1.48)
Specific Activity	> 500 U/mg protein (After activation)
Unit Definition	One unit will produce a change in A₂₈₀ of 0.001 per minute at pH 2.0 and 37°C, measured as TCA-soluble products from hemoglobin.
Appearance	White to off-white powder
Solubility	Clear, colorless liquid (1 mg/mL saline)
Reconstitution	After reconstitution maintain at or above pH 8.0 to avoid activation.
Formulation	Lyophilized from tris-chloride, pH 8.5.
Related Products	440-52 - Pepsinogen II from human gastric mucosa 441-10 - Pepsin 1:10,000 from porcine gastric mucosa 435-10 - Mucin from porcine gastric mucosa
Recertification	3 years
Storage	-20°C
Infectious Disease Testing	Negative or non-reactive at the donor level for anti HIV 1 and 2, anti HCV, syphilis (RPR) and HBsAg by FDA approved methods
Molecular Weight	40,300
Synonyms	Pepsinogen A, PG I, PGA, Pepsinogen 1
E.C. Number	3.4.23.1
Gene	PGA3, PGA4, PGA5