Low Density Lipoprotein (LDL)
| Product Name | Low Density Lipoprotein |
| Source | Human Plasma |
| Catalogue Number | 360-30 |
| Formulation | 0.2 micron filtered solution in phosphate buffered saline, pH 7.4 with 0.3 mM EDTA and 0.05% ProClin™ 300 |
| Form | Liquid |
| Purity | > 95% (SDS-PAGE) |
| Appearance | Yellow to orange liquid |
| Protein | 5 - 8 mg/mL (Modified Lowry) |
| LDL Cholesterol | > 500 mg/dL (Enzymatic) |
| Total Cholesterol | > 500 mg/dL (Enzymatic) |
| Triglyceride | Report in mg/dL (Enzymatic) |
| Triglyceride Ratio | < 0.50 |
| Electrophoresis | One major band consistent with LDL, HDL not detected (Helena QuickGel® Cholesterol) |
| Related Products | 360-10 - LDL Concentrate from human plasma 360-31 - High Purity Copper Oxidized LDL from human plasma |
| Storage | 2-8°C |
| Recertification | 6 months from date of manufacture |
| Infectious Disease Testing | Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HIV-1 (NAT), HBV (NAT), HCV (NAT), and syphilis by FDA approved methods. |
| Synonyms | LDL, LDL-C, Beta-Lipoprotein, Concentrate, Fraction |
| Country of Origin | United States |
Lee Biosolutions is world leader in the manufacturing of human plasma lipoproteins, including native antigens and modified LDL and HDL for research and in vitro diagnostic (IVD) manufacturing uses.
Custom LDL/HDL and triglyceride ratios, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
OVERVIEW
Low-density lipoprotein (LDL), often deemed the “bad cholesterol”, is a lipoprotein that carries cholesterol throughout the body via blood circulation. Due to its role in dispositioning cholesterol TO tissues and organs of the body, having high levels of LDL can lead to plaque formation in the arteries, possibly increasing the risk of heart disease and stroke.
It is recommended by the National Heart, Lung, and Blood Institute to maintain a LDL cholesterol level lower than 100 mg/dL, optimally.
APPLICATIONS
Diagnostic – Clinical calibration control
Source of antigens for developing antibodies
Cholesterol Research in regards to pharmaceutical drug development and familial hypercholesterolaemia
Developing new methods of LDL measurement
EMERGING RESEARCH
LDL size has been shown to be linked to cardiovascular health. The larger the LDL particles, the greater correlation to a cardiovascular event.
Lowering LDL to the levels of a new-born baby has been shown to dramatically decrease the risk of heart disease.
Direct homogeneous assays rather than determining LDL-C values based on the Friedewald calculation may improve lipoprotein analyses and allow for a more accurate LDL value, especially in regards to patients suffering from hyperlipidemia
Lee Biosolutions, Inc
