Haptoglobin (Hp)
Product Name | Haptoglobin |
Source | Mouse Serum |
Catalogue Number | 334-11 |
Purity | > 90% (SDS-PAGE) |
Form | Liquid |
Protein | > 0.5 mg/mL (Coomassie) |
Formulation | Solution in 0.01 M sodium phosphate, 0.15 M sodium chloride, 0.09% sodium azide, pH 7.2 |
Appearance | Frozen solution |
Recertification | 2 years |
Storage | -20°C |
Molecular Weight | alpha Hp: ~10,000 beta Hp: ~40,000 |
CAS Number | 9087-69-8 |
Synonyms | Hp |
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Haptoglobin (frequently abbreviated as Hp) is a protein in the blood plasma that binds free hemoglobin released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). Haptoglobin is a serum protein that consists of two alpha and two beta chains connected by disulfide bridges. It acts as a hemoglobin scavenger and has been associated with protease inhibitory activity. It is a positive acute phase reactant, the levels of which increase significantly in mice in response to inflammation, tissue injury or disease.